Jakub Skóra, Olga Zhurakivska, Sergiy Kindrativ, Kindrativ E., Kniazevych-Chorna T.
Department of pathological anatomy
Ivano-Frankivsk National Medical University, Ukraine
Toufik’s Medical Journal
Volume 1, Supplement 1, November 2021
Abstract from Biomedical Perspectives III
Introduction: Nowadays the role of viral infections in the etiology of chronic women’s inflammatory disease and development of female infertility is actively investigated and studied in many countries. The human papillomavirus (HPV) attracts a lot of attention, because it occupies one of the major positions in development of female genital diseases.
Aim: To establish the prevalence of HPV infection in women with different forms of infertility and identify the pathomorphological features of cervical intraepithelial neoplasia.
Material and Methods: In research were used clinical data (results of colposcopy) from inpatient and outpatient charts of 157 women with CIN, the real-time PCR for detection of viral DNA HPV with high carcinogenic risk (HCR) and morphological (histological, histochemical, immunohistochemical) methods.
Results: The initiating factor in the development and progression of neoplastic transformation of the cervix in women with infertility should be considered HPV of WRC, as evidenced by the significant advantage (62,8%) infected patients and increase the frequency of detection of HPV by increasing the degree of severity of CIN. Hormonal and uterine infertility accounted for the same proportion – 22,2%. Characterized by the lowest rate trumpet and combined infertility. These forms also form the same proportion (11,1%). When focal and diffuse expression levels observed prevalence of tubal infertility, which is respectively 44,4% and 52,9%. In CIN II, CIN as in-and the highest rate of negative expression р16ink4a belongs peritoneal infertility. Tubal infertility also prevails in the focal and diffuse expression of the marker, and is respectively 61,8% and 50,0%. Unlike CIN-I, in the group increases the proportion of patients with combined infertility, which is 25.0%. When CIN-III at 100,0% observed positive dysplastic epithelium on р16ink4a expression. Among the types of infertility installed in patients with severe dysplasia dominated tubal infertility.
Conclusions: By colposcopy examination clinical form of infection with human papilloma virus is observed in 31.6% of women with infertility. Other colposcopic signs of HPV infection are non-specific, because there are signs of cervical intraepithelial neoplasia. The presence of genital warts in 13.6% of women can be seen as cervical factor that can prevent fertility except the specified type of infertility in patients.