Introduction: Blood is a media for various immune cells and signalling molecules (cytokines, chemokines and growth factors). Signalling molecules exert complex influence over blood cells, i.e. lymphocytes release signalling molecules and respond via proliferation or apoptosis. Increased levels of such signalling molecules, as sera markers (CRP, BAFF, TARC, angiogenin, serpin E1, RBP-4, EGF, PDGF-AA), along with increased levels of T- and B-lymphocytes have been reported in children with CP.

Aim: To determine the link between increased levels of sera markers and lymphocytes in children with CP.

Materials and methods: Biological meaning behind increased levels of such products of gene activity, as sera markers (CRP, BAFF, TARC, angiogenin, serpin E1, RBP-4, EGF, PDGF-AA) and increased levels of T- and B-lymphocytes in children with CP compared to healthy children was defined by statistical approach using the Database for Annotation, Visualization and Integrated Discovery (DAVID).

Results: Sera makers (BAFF, EGF, PDGF-AA) were associated with anti-apoptotic processes in lymphocytes.

Conclusions: Increased levels of sera anti-apoptotic markers resulted in reduction of apoptosis in T- and B-lymphocytes. Correspondingly, we observed increased levels of lymphocytes.