Introduction: Psammomatous meningiomas are characterized by an accumulation of psammoma bodies − microcalcifications, which are a manifestation of pathological biomineralization. 

Aim: This research aims to study the basic morphological properties of calcifications in tumors of the dura mater. 

Materials and methods. We examined 30 samples of psammomatous meningioma with calcifications by using haematoxylin and eosin, Van Gieson and von Kossa staining.

Results: Meningiomas are rubbery or firm, well-demarcated rounded masses that feature broad dural attachment. The longitudinal section of meningioma’s revealed the presence of solid biomineral deposits, which were cut with effort. Histological examination shows uniform tumor cells, which form lobules. They have oval nuclei with delicate chromatin that show central clearing or the formulation of cytoplasmic-nuclear inclusions. Van Gieson stain reveals the presence of spindle cells, which forming parallel, storiform, and interlacing bundles in a collagen-rich matrix. Also, we can see thin collagenous septae, which partly demarcate tumor lobules. The neoplastic cells have a transitional appearance with whorl formation. Psammoma bodies were painted in brown with silver salts by using von Kossa staining. Some tumors are almost entirely replaced by psammoma bodies. That confirms that the mineral composites in the tissue of psammomatous meningiomas contain calcium phosphates.

Conclusions: Some tumors are almost completely replaced by psammoma bodies, and tissue has a brownish color. A significant amount of connective tissue in psammomatous meningiomas forms whorls and collagen bundles, which were established using Van Gieson staining. The mineral composites in the tissue of psammomatous meningiomas contain calcium phosphates.