Introduction: In critical conditions, endotoxemia, systemic inflammation, an increase in lipid content and a change in the profile of lipoproteins in the blood have a stereotypical protective character and contribute to the survival of the body, which suggested a possible leading role for lipid metabolism disorders, cholesterol (CS), serum lipoprotein concentration (HDL LDL), triglycerides (TG) in the development of generalization of systemic inflammation, binding and neutralization of bacterial toxins.

Aim: To reveal the patterns of lipid metabolism disorders in patients with concomitant trauma during intensive therapy in order to predict the course of trauma.

Material and methods:  The study included 56 patients with severe concomitant trauma, severity according to the APACHE II scale over 17 points, 37 surviving patients (group 1) and 19 dead patients (group 2). In the course of intensive therapy (1, 3, 5, 7 and 10 days), a study was carried out indicators of lipid metabolism: cholesterol (CS), triglycerides (TG), high density lipoproteins (HDL) and low density lipoproteins (LDL).

Results: Comparative assessment of changes in lipid metabolism parameters showed that the concentration of cholesterol in both groups was lower than normal values, and significantly lower by 21% in the group of dead patients. The content of triglycerides in the blood serum increased from the 1st to the 7th day, and by the 10th day it was significantly higher in the group of deaths by 28%. In general, the group of deceased patients was characterized in comparison with the group of survivors by a significantly lower level of cholesterol by (18-23%) at all stages of the study, a significant decrease in serum HDL concentration with a significant difference on the 5th day between survivors and deaths, a significantly greater increase the level of TG by the 10th day, with an excess of the values of these indicators relative to the norm in the group of deceased.

Conclusions: 1. The study revealed features of lipid metabolism disorders in severe concomitant trauma. This allowed us to consider serum cholesterol levels less than 2 mmol / L, an increase in serum triglyceride levels of more than 2.3 mmol / L, a decrease in HDL, LDL as an additional criteria for the severity and possible predictors of an unfavorable clinical outcome of concomitant injury.