Introduction: Anti-Mullerian hormone (AMH) is one of the factors that directly affects on the development of gonads in the early embryonic period. Although the role of AMH remains not completely studied, there is an assumption that this factor can cause pathological changes in a female reproductive system. There are some difficulties in establishing a diagnosis of metabolic syndrome (MS) in adolescents. This is due to the peculiarities of reproductive and endocrine systems in this age group. Therefore, it is important to have clear criteria in order not to allow both hyper diagnostic and late detection.

Aim: To determine the level of AMH and analyze its indicators in adolescent girls with MS.

Materials and methods: The research was conducted on the basis of the Sumy Regional Clinical Perinatal Center during 2018 – 2020. In this study 84 girls aged 13 to 19 have taken part. The following groups were formed: 44 girls with MS came into the main group; 40 healthy girls were in control group. For girls in all groups determined the level of AMH in blood serum at the first phase of the menstrual cycle. The research used an immunochemical method with electrochemiluminescence detection with the help of a test system Cobas 600, Roche Diagnostics (Switzerland).

Results: As a result of the analysis in girls of the main group with MS revealed a statistically significant decrease in AMH in comparison with healthy girls in the control group: ± 1.1 ng / ml and 6.5 ± 1.2 ng / ml, respectively. It should be admitted that among girls of the main group with MS, menstrual irregularities were significantly more common. Using a detailed medical history, it was found that 36 (81.8%) girls had pathological age of menarche (<11 years and> 16 years) and / or irregular menstrual cycle. So, the detection of differences in the level of AMH between groups only confirms the presence of disorders of the reproductive system in adolescent girls with MS.

Conclusions: Given the peculiarities of ovarian ultrasound in the first 8 years after menarche, and the lack of clear diagnostic criteria for MS in adolescents, AMH can be used as an alternative marker of ovulatory dysfunction in adolescent girls. Understanding the pathogenic effects of AMH on the female reproductive system suggests that restoring normal levels of this factor will improve reproductive outcomes in women. Therefore, this is a promising area for research.