Introduction: According to official statistics, atopic dermatitis (AD) in Ukraine occurs in 3-10 cases per 1,000 children. This differs from the results obtained during studies under the standardized international program ISAAC (International Study of Asthma and Allergies in Childhood), which exceed these indicators by 5-10 times. Due to the variety of pathogenetic mechanisms of blood pressure development, modern dermatologists face a difficult task – to treat patients without harming them or inconvenience.

Aim: To evaluate the effectiveness of external therapy without the use of topical glucocorticoids.

Results: Content of work. Under observation were 64 children aged 6 months to 6 years with manifestations of exacerbation of hypertension. The children will be divided into two groups. And the group – children of early age (up to 3 years) numbering 31 children. Preschool children (3-6 years old) with 33 children were concentrated in group II. According to gender characteristics, in group I the number of girls and boys was almost the same, respectively 52% and 48%, in group II boys prevailed by 52% (p≤0.01). The nature of breastfeeding in the first year of life in both groups was dominated by breastfeeding, which accounted for the vast majority of cases (> 60%), and manifestations of atopy in the family occurred in both groups: 57% in the first and 56.5% in the second. groups. In no case was the exacerbation associated with a diet disorder. All children received treatment according to the protocol of diagnosis and treatment of children with atopic dermatitis (Order of the Ministry of Health of Ukraine dated 24.12.2005 № 767). The division into subgroups was due to the refusal to use topical glucocorticosteroids in favor of a topical blocker of calcineurin. According to the results of observations, objective symptoms of the intensity of the allergic inflammatory process, such as erythema, wetting disappeared significantly (p <0.05) previously in patients who used a topical blocker of calcineurin. In group I, it was observed on day 8.62 of treatment, which is 0.2 days (p> 0.05) later than children in the older group. Subjective symptoms (complaints of itching, poor sleep) disappeared almost simultaneously in all subgroups (2.2 – 2.3 days of treatment). During the examination, 9 patients refused external therapy (antihistamines were prescribed as basic therapy). In these cases, the results of treatment were ineffective.

Conclusions: 1. The use of a topical blocker of calcineurin makes it possible to reliably (p <0.05) previously obtain a positive effect of therapy.
2. Subjective signs of intensity of BP manifestation were eliminated almost equally on the background of topical glucocorticosteroids and topical calcineurin blocker.
3. The overestimated role of hypoallergenic nutrition in the treatment of children with hypertension. 4. The use of antihistamines of the first, second generation as monotherapy is not justified.