Introduction: Peptic ulcer disease (PUD) is a chronic disease, the main feature of which is the formation of ulcerative defects in the mucous membrane of the stomach or duodenum, has a cyclical nature and proceeds with periods of exacerbation and remission. According to statistics, from 6 to 14% of the population in different parts of the world suffer from ulcer disease. Children account for 1% of the incidence. Most often, men aged 40-60 are affected.

Aim: To improve the results of treatment of patients with PUD.

Materials and methods: The experience of diagnostics and treatment of 50 patients with PUD in several district hospitals of the Kirovograd region is analyzed. There were 18 females (36%) and 32 males (64%). Age of patients ranges from 21 to 79 years.

Results: According to the results of the last 2 years, all patients had standard symptoms characteristic of peptic ulcer disease, among which relapses were found in 12% of men from the surveyed number, mainly with similar forms of the disease, but there were no recurrent cases in women from this sample. In patients under constant supervision for gastrointestinal diseases, the number of relapses decreased from 10% of cases per year to 4%. Patients with recurrent disease had a negative test result during Helicobacter pylori control. Of the total number of relapses, 4 cases of massive gastric bleeding and 2 cases of perforation were confirmed. The mortality rate last year was 0%. The number of operations performed in 2 years – 3, namely: suturing of a perforated ulcer – 1, gastrotomy according to Billroth-2 – 2. The use of standard treatment regimens gave a positive result, 89% of patients are in remission, and 11% continue the course. Outpatient treatment accounts for 37% of the total, inpatient – 63%.

Conclusions: Nowadays, peptic ulcer disease is very common, but there is a tendency towards a decrease in the number of patients with complicated forms of peptic ulcer disease, due to the effectiveness of modern antiulcer therapy regimens, an increase in the availability of endoscopic diagnostics and the use of screening tests to clarify the presence of Helicobacter pylori, and successful eradication therapy radically changes the course disease, preventing its recurrence.