Introduction: Vitamin D deficiency is a common problem worldwide, constantly increasing with the urbanization level. It can cause many diseases, anxiety and depression, especially in adolescence. WHO defines Quality of Life as an individual’s perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns.

Aim: to determine Vitamin D effect  on the adolescent quality of life 

Materials and methods:  The study was conducted by questioning 177 students of Municipal Institution of Sumy Regional Council “Sumy Professional Medical College” (25 boys and 152 girls aged 15 to 18). The main group consisted of 22 students (12%) who took vitamin D (5 students or 22.7% in the form of monovitamin D and 17 students (77.3%) in multivitamins), others (155 students or 88%) were the control group.

Results: Depressive mood predisposition noted at 3 (13.6%) of those who take vitamin D, 8 (36.4%) students have proneness to SARS; 18 students (81.8%) are more motivated and active in self-realization. At the same time, in students of the control group, these indicators differed significantly and amounted to 33.3%, 52.3% and 40.6%, respectively.

Conclusions: Those students who take vitamin D have lower incidence of SARS and depressed mood. Students who do not take vitamin D are less focused and motivated. Vitamin D intake is insufficient among students.