Introduction. Acute appendicitis is the most common urgent surgical disease with various manifestations and complications.

Aim. To analyze the use of lymphotropic antibacterial therapy in the treatment of patients with acute appendicitis as a method alternative to standard antibacterial therapy, which can improve the treatment of such patients.

Materials and methods. Patients were divided into two groups. The main group included patients who were administered antibiotics and pathogenetic drugs regionally to the ileocecal zone by lymphotropic route. The comparison group included patients who received standard antibiotic therapy.

Results: On the 5th day of the postoperative period, the level of Ig A in the main group was 1,16 + 0,7 mg / ml, and in the comparison group – 1, 54 + 0,8 mg / ml. The level of elastase in the operated main group decreased to 111,797 ± 21,39 nmol / min • ml, ie 2,4 times (p <0,001), and in patients of the comparison group – to 179,605 ± 26,79 nmol / min • ml, ie 1,5 times (p <0,05). Under the influence of lymphotropic administration of the antibiotic, the volume of the spleen decreased by 5 days to 281,22 + 18,8 cm³, ie 145,44 cm3, and with standard administration of antibiotics, the spleen in the study period decreased to 344,71 ± 21,13 cm³, ie by 79,54 cm3, which is less than in the main group by 66 cm³, or 1,8 times (p <0,05).

Conclusion: The introduction of antibiotics and pathogenetic drugs by lymphotropic regionally to the ileocecal zone provides adequate accumulation in the tissues of the vermiform process, which is not observed with their traditional introduction, which provides reliable antibacterial sanitation of this zone. The proposed method of antibiotic therapy improves the results of treatment of patients with acute appendicitis, reduces their length of stay in the hospital, which has a positive impact on financial problems. The use of lymphotropic therapy in acute appendicitis is a method of prevention of purulent-septic complications, especially in its destructive forms, which improves the results of treatment of patients with acute destructive appendicitis.