Introduction: There are over 30 million PLWH nowadays, and due to advances in HIV treatment, it is a chronic and manageable medical condition. Anxiety and depression are clinically crucial for PLWH because they affect their quality of life, sleep patterns, adherence to antiretroviral therapy (ART), cognitive function and can weaken patients’ immune systems.

Aim: Review of recent studies.

Material and methods: Using databases Pubmed, Scopus.

Results: The frequency and severity of depression and anxiety in PLWH is significant and exceeds 3.4-4 times the corresponding indicators of the healthy Ukrainian population. Depression, in particular, is common among PLWH, with an estimated prevalence of 20% to 40% PLWH. Apathy is common in HIV, separable from depression, and has been associated with non-adherence to ART. Numerous studies have reported that post-traumatic stress disorder (PTSD) rates are disproportionately higher in PLWH than in the average population. The prevalence of generalized anxiety disorder (GAD) and PTSD is estimated at the rate of 16% and 10-74% correspondingly, compared with 2% and 8% among the average population.  The dependence between GAD, PTSD and an HIV diagnosis may be stronger in adults over 65 than 50-64 years old. Psychiatric comorbidities may serve as significant predictors of suicide risk among PLWH. About 21% of PLWH report suicidal ideation, a complete 5% report a past-year suicide attempt, and 1-2% die by suicide. The peak of suicidal ideation and attempts occurs approximately 1-2 years after diagnosis. 

Conclusions. The relevance of further in-depth investigation to the mechanisms for the formation of non-psychotic mental disorders among PLWH is substantiated.