Introduction: Purulent-inflammatory diseases, including trophic ulcers (TU) of the lower extremities, are an essential problem of modern surgery [1], because according to statistics, 1-3% of the population have TU of venous origin [2], and the cost of treatment is 1% of the protection budget health in Western countries [3]. 

Aim: Study of the effect of hydroxyapatite and zinc oxide on the purulent process, healing of TU.

Materials and methods: The proposed biocomposite apatite – polymer drainage dressings (APDD) can be used to treat patients with TU of venous or arterial origin, including due to microcirculation disorders in diabetes. APDD is a macroporous threedimensional grid – a matrix with a thickness of 7–10 mm, obtained by multistage synthesis, which includes ultrasonic homogenization of the suspension of the initial components (calcium deficient hydroxyapatite, zinc oxide, sodium alginate) with the subsequent sublimation process. Due to its components, APDD has properties inherent in hydrophobic and hydrophilic sorbents, as well as anti-inflammatory, detoxifying and bactericidal properties, stimulates fibroblast proliferation, angiogenesis of capillaries and lymphatic vessels, improves and accelerates tissue regeneration.

Results and conclusions: According to the results of clinical observation of 17 patients treated by us on the basis of the Department of Vascular Surgery SRKH Sumy, the following conclusions can be drawn: 1. In the treatment of patients with TU, it is advisable to use APDD, effective improvement and restoration of objective indicators without the use of antibacterial drugs. 2. The use of APDD is accompanied by a decrease in local pain, nocturnal pain in the calves, edema, peripheral hyperemia, wound exudation, heaviness in the affected limb, improved foot function and accelerates the healing time of the ulcer defect.