Introduction: β-adrenergic antagonists are used to treat a lot of cardiovascular diseases. Because development of cardiovascular pathology is commonly accompanied by chronic renal failure, investigation of β-adrenergic antagonist influence on the renal function is important. It is known that some β-adrenergic antagonists increase renal circulation, diuresis and sodium excretion and renal dopamine receptors take part in the mechanism of tubular and vascular effects of some drugs. These data were received in acute experiments on narcotizated animals.        

Aim: The work aim was investigation of dopamine receptor role in the mechanism of talinolol action on renal circulation and urine sodium excretion in unnarcotizated rats in chronic experiment with water load to exclude anaesthesia influence on investigation data.     

Materials and methods: Experiments fulfilled on 25 white male rats with mass 200-250g received standard foods and having free access to water. Preliminarily, the rats were operated to create microcystis to allow more correct urine collection. The rats were taken for experiments in 2 weeks after operation. Renal function was estimated under the background of 3% water load. Kallikrein was determined in urine by standard method. Sodium concentration was determined by flame photometry. All indicators were calculated on 100g of rat body weight. Talinolol was administered intraperitoneally in dose 1mg/kg. Dopamine receptor antagonist haloperidol (1 mg/kg) was administered subcutaneously.

Results: It has shown that haloperidol and talinolol combination has not to change renal function of unnarcotizated rats in comparison with result received for talinolol itself. Talinolol action itself on the unnarcotizated rats did not lead to significant change of diuresis volume and urine electrolytes excretion. Unreliable inhibition of renal excretion of sodium and potassium was observed at talinolol and haloperidol combination. The urination volume tends to decrease too. Glomerular filtration volume did not change reliably.  

Conclusions: Experiments were found that dopamine receptors do not participate in the formation of investigated renal function indicators under the background of talinolol action.