Introduction: Glioblastoma is one of the most common tumors of the central nervous system, accounting for about 62% of all astrocytic tumors. Glioblastoma is very prone to recurrence and metastasis. The prognosis for patients with glial tumors of the brain is extremely unfavorable. The survival rate of patients with glioblastoma after 5 years after combined therapy is quite low – 10%. That is why the study of the course, pathomorphological changes of organs in patients with glioblastoma remains relevant. 

Aim. To carry out a clinical analysis of the course and identify morphological featues of glioblastoma of the frontal lobe of the left hemisphere of the brain. 

Materials and methods: An analysis of the medical history of a 36-year-old patient was performed. During the pathomorphological examination of the woman skull trepanation, macroscopic examination, sampling for further microscopic examination (hematoxylin and eosin staining) were performed. The study is according to the m   and ethical principles of the Declaration of Helsinki. 

Results: After the analysis of the medical history, it was established that the patient had been ill since 2017. The main complaint of the patient was a headache. According to the clinical examination, the diagnosis was: Neoplasm of the left frontal lobe of the brain. Radical removal of the tumor was performed on 12.12.2017, histological diagnosis is glioblastoma. Recurrence of a neoplasm of the left frontal lobe of the brain was detected a year after surgery. The patient died 1.5 years after diagnosis, with a postmortem diagnosis: prolongatio morbi, cerebral edema, plethora and parenchymal dystrophy of internal organs. At pathological examination macroscopically: a neoplasm of the left frontal lobe of the brain with germination in the dura mater and the wall of the left lateral ventricle. Microscopically: tissue edema, vascular plethora, glioblastoma germination, peripheral vascular growth, necrosis, hemorrhage, hemosiderophages and diffuse lymphocytic infiltration. Glioblastoma progressed rapidly in this case, lifespan from the time of diagnosis is 1.5 years and from the moment of surgical treatment of recurrence was 6 months.

 Conclusions: Thus, the results of the study confirm that glioblastoma of the brain is a malignant tumor with rapid progression, frequent development of recurrences and complications, severe course and a very unfavorable prognosis for the life of patients.